Gene information
Official symbol IL6
Official full name interleukin 6
Gene type protein-coding gene
Chromosome7p15.3
Alias symbolIL-6; BSF2; HGF; HSF
Previous symbolIFNB2
Gene familyInterferons; Interleukins; Interleukin 6 type cytokine family
Resources
Entrez Gene 3569
HGNC HGNC:6018
Ensembl ENSG00000136244
Vega OTTHUMG00000023178
UCSC uc064bxs.1
GO terms: 327 records
GO Description Category LogP Number of genes Detail
GO:0000302 response to reactive oxygen species GO Biological Processes -13.4775134 34 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0001776 leukocyte homeostasis GO Biological Processes -5.24665798 8 More
GO:0001816 cytokine production GO Biological Processes -9.14810130 8 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001819 positive regulation of cytokine production GO Biological Processes -44.1872667 64 More
GO:0001889 liver development GO Biological Processes -10.3922429 25 More
GO:0001894 tissue homeostasis GO Biological Processes -10.3152206 20 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0001960 negative regulation of cytokine-mediated signaling pathway GO Biological Processes -11.0318814 22 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002250 adaptive immune response GO Biological Processes -8.22919489 29 More
GO:0002251 organ or tissue specific immune response GO Biological Processes -5.08329154 5 More
GO:0002252 immune effector process GO Biological Processes -24.2648770 43 More
GO:0002262 myeloid cell homeostasis GO Biological Processes -5.37317748 10 More
GO:0002263 cell activation involved in immune response GO Biological Processes -10.3401505 18 More
GO:0002285 lymphocyte activation involved in immune response GO Biological Processes -7.04246662 12 More
GO:0002286 T cell activation involved in immune response GO Biological Processes -5.33688125 8 More
GO:0002287 alpha-beta T cell activation involved in immune response GO Biological Processes -5.32260704 6 More
GO:0002292 T cell differentiation involved in immune response GO Biological Processes -5.02945267 6 More
GO:0002293 alpha-beta T cell differentiation involved in immune response GO Biological Processes -5.32260704 6 More
GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response GO Biological Processes -5.40213264 6 More
GO:0002312 B cell activation involved in immune response GO Biological Processes -4.27715369 6 More
GO:0002313 mature B cell differentiation involved in immune response GO Biological Processes -2.3845323 3 More
GO:0002314 germinal center B cell differentiation GO Biological Processes -3.92643717 3 More
GO:0002335 mature B cell differentiation GO Biological Processes -2.15864942 3 More
GO:0002366 leukocyte activation involved in immune response GO Biological Processes -10.4998832 18 More
GO:0002443 leukocyte mediated immunity GO Biological Processes -15.2263375 27 More
GO:0002444 myeloid leukocyte mediated immunity GO Biological Processes -7.71730059 9 More
GO:0002446 neutrophil mediated immunity GO Biological Processes -8.04833674 7 More
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -11.9339394 22 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002521 leukocyte differentiation GO Biological Processes -12.4650129 27 More
GO:0002526 acute inflammatory response GO Biological Processes -34.5980034 29 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0002637 regulation of immunoglobulin production GO Biological Processes -8.47662495 11 More
GO:0002639 positive regulation of immunoglobulin production GO Biological Processes -6.83160707 8 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0002675 positive regulation of acute inflammatory response GO Biological Processes -10.8573789 13 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002687 positive regulation of leukocyte migration GO Biological Processes -31.0737422 33 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002690 positive regulation of leukocyte chemotaxis GO Biological Processes -28.1480961 27 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0002697 regulation of immune effector process GO Biological Processes -33.2683521 48 More
GO:0002699 positive regulation of immune effector process GO Biological Processes -18.3926498 29 More
GO:0002700 regulation of production of molecular mediator of immune response GO Biological Processes -19.7615296 26 More
GO:0002702 positive regulation of production of molecular mediator of immune response GO Biological Processes -12.4206918 17 More
GO:0002703 regulation of leukocyte mediated immunity GO Biological Processes -18.0432682 27 More
GO:0002705 positive regulation of leukocyte mediated immunity GO Biological Processes -8.38274670 14 More
GO:0002706 regulation of lymphocyte mediated immunity GO Biological Processes -13.7265777 21 More
GO:0002708 positive regulation of lymphocyte mediated immunity GO Biological Processes -8.31079168 13 More
GO:0002709 regulation of T cell mediated immunity GO Biological Processes -8.74858930 12 More
GO:0002711 positive regulation of T cell mediated immunity GO Biological Processes -6.00483593 8 More
GO:0002718 regulation of cytokine production involved in immune response GO Biological Processes -15.9157324 18 More
GO:0002720 positive regulation of cytokine production involved in immune response GO Biological Processes -8.11676834 10 More
GO:0002724 regulation of T cell cytokine production GO Biological Processes -9.29772341 9 More
GO:0002726 positive regulation of T cell cytokine production GO Biological Processes -6.29956701 6 More
GO:0002790 peptide secretion GO Biological Processes -5.12832495 12 More
GO:0002791 regulation of peptide secretion GO Biological Processes -16.5189310 23 More
GO:0002819 regulation of adaptive immune response GO Biological Processes -16.0189388 24 More
GO:0002821 positive regulation of adaptive immune response GO Biological Processes -12.1298033 16 More
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -14.6775052 22 More
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO Biological Processes -10.1498702 14 More
GO:0002828 regulation of type 2 immune response GO Biological Processes -8.52846045 8 More
GO:0002830 positive regulation of type 2 immune response GO Biological Processes -7.53000143 6 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005126 cytokine receptor binding GO Molecular Functions -41.4908940 50 More
GO:0005788 endoplasmic reticulum lumen GO Cellular Components -47.2996164 57 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0006953 acute-phase response GO Biological Processes -24.9631834 19 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0006959 humoral immune response GO Biological Processes -20.5068158 33 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009615 response to virus GO Biological Processes -11.2861143 47 More
GO:0009617 response to bacterium GO Biological Processes -52.1760880 83 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009914 hormone transport GO Biological Processes -6.35710158 16 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010543 regulation of platelet activation GO Biological Processes -12.2843439 12 More
GO:0010573 vascular endothelial growth factor production GO Biological Processes -10.4763648 6 More
GO:0010574 regulation of vascular endothelial growth factor production GO Biological Processes -24.2705452 18 More
GO:0010575 positive regulation of vascular endothelial growth factor production GO Biological Processes -10.362168 13 More
GO:0010712 regulation of collagen metabolic process GO Biological Processes -14.4967625 19 More
GO:0010713 negative regulation of collagen metabolic process GO Biological Processes -7.99383323 8 More
GO:0010715 regulation of extracellular matrix disassembly GO Biological Processes -5.83914312 5 More
GO:0010717 regulation of epithelial to mesenchymal transition GO Biological Processes -12.1292389 25 More
GO:0010718 positive regulation of epithelial to mesenchymal transition GO Biological Processes -11.466629 18 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010721 negative regulation of cell development GO Biological Processes -6.74707916 25 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010883 regulation of lipid storage GO Biological Processes -22.5241589 19 More
GO:0010888 negative regulation of lipid storage GO Biological Processes -13.5596033 10 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0014013 regulation of gliogenesis GO Biological Processes -13.3514185 26 More
GO:0014015 positive regulation of gliogenesis GO Biological Processes -11.0528361 19 More
GO:0014823 response to activity GO Biological Processes -19.5783025 27 More
GO:0015833 peptide transport GO Biological Processes -4.22542842 7 More
GO:0019221 cytokine-mediated signaling pathway GO Biological Processes -27.5840932 43 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0022612 gland morphogenesis GO Biological Processes -7.35048069 19 More
GO:0023061 signal release GO Biological Processes -5.50151396 21 More
GO:0030072 peptide hormone secretion GO Biological Processes -4.51947106 11 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030098 lymphocyte differentiation GO Biological Processes -7.22308617 17 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030168 platelet activation GO Biological Processes -17.9354931 20 More
GO:0030183 B cell differentiation GO Biological Processes -4.52538214 9 More
GO:0030217 T cell differentiation GO Biological Processes -5.22709721 11 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0031016 pancreas development GO Biological Processes -6.43498850 15 More
GO:0031018 endocrine pancreas development GO Biological Processes -4.66781085 9 More
GO:0031099 regeneration GO Biological Processes -17.4553316 23 More
GO:0031100 animal organ regeneration GO Biological Processes -17.1438387 17 More
GO:0031175 neuron projection development GO Biological Processes -7.36986002 58 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031960 response to corticosteroid GO Biological Processes -20.1789519 26 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032494 response to peptidoglycan GO Biological Processes -3.23941104 3 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032653 regulation of interleukin-10 production GO Biological Processes -10.1959901 18 More
GO:0032660 regulation of interleukin-17 production GO Biological Processes -6.79373102 8 More
GO:0032675 regulation of interleukin-6 production GO Biological Processes -28.2553997 51 More
GO:0032677 regulation of interleukin-8 production GO Biological Processes -20.0046302 33 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032682 negative regulation of chemokine production GO Biological Processes -6.18749803 9 More
GO:0032722 positive regulation of chemokine production GO Biological Processes -22.4503100 21 More
GO:0032731 positive regulation of interleukin-1 beta production GO Biological Processes -11.8061175 13 More
GO:0032732 positive regulation of interleukin-1 production GO Biological Processes -14.7376831 16 More
GO:0032733 positive regulation of interleukin-10 production GO Biological Processes -8.60591296 9 More
GO:0032755 positive regulation of interleukin-6 production GO Biological Processes -18.6559032 31 More
GO:0032757 positive regulation of interleukin-8 production GO Biological Processes -14.6396218 15 More
GO:0032760 positive regulation of tumor necrosis factor production GO Biological Processes -21.1788990 23 More
GO:0032940 secretion by cell GO Biological Processes -8.42144465 43 More
GO:0032944 regulation of mononuclear cell proliferation GO Biological Processes -24.6915018 34 More
GO:0032946 positive regulation of mononuclear cell proliferation GO Biological Processes -20.2231223 25 More
GO:0032965 regulation of collagen biosynthetic process GO Biological Processes -13.1192794 17 More
GO:0032966 negative regulation of collagen biosynthetic process GO Biological Processes -6.82460421 7 More
GO:0033135 regulation of peptidyl-serine phosphorylation GO Biological Processes -8.68560410 14 More
GO:0033138 positive regulation of peptidyl-serine phosphorylation GO Biological Processes -6.77396219 11 More
GO:0033500 carbohydrate homeostasis GO Biological Processes -23.7918768 50 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034104 negative regulation of tissue remodeling GO Biological Processes -6.91942497 9 More
GO:0034110 regulation of homotypic cell-cell adhesion GO Biological Processes -6.42713539 7 More
GO:0034250 positive regulation of cellular amide metabolic process GO Biological Processes -3.04911747 8 More
GO:0034599 cellular response to oxidative stress GO Biological Processes -11.6255265 36 More
GO:0034614 cellular response to reactive oxygen species GO Biological Processes -9.93259803 24 More
GO:0035270 endocrine system development GO Biological Processes -10.2307745 25 More
GO:0035633 maintenance of blood-brain barrier GO Biological Processes -4.09043632 8 More
GO:0035710 CD4-positive, alpha-beta T cell activation GO Biological Processes -4.53716649 6 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042093 T-helper cell differentiation GO Biological Processes -5.40213264 6 More
GO:0042102 positive regulation of T cell proliferation GO Biological Processes -13.4787271 17 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042113 B cell activation GO Biological Processes -5.56585733 12 More
GO:0042129 regulation of T cell proliferation GO Biological Processes -18.0871480 25 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.4049069 20 More
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO Biological Processes -19.8380655 19 More
GO:0042542 response to hydrogen peroxide GO Biological Processes -8.84445919 13 More
GO:0042593 glucose homeostasis GO Biological Processes -23.8963802 50 More
GO:0042742 defense response to bacterium GO Biological Processes -25.9215771 41 More
GO:0042886 amide transport GO Biological Processes -5.62242821 10 More
GO:0043030 regulation of macrophage activation GO Biological Processes -14.6396218 15 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043367 CD4-positive, alpha-beta T cell differentiation GO Biological Processes -4.83197184 6 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0045124 regulation of bone resorption GO Biological Processes -6.02130395 7 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045596 negative regulation of cell differentiation GO Biological Processes -26.9785067 101 More
GO:0045598 regulation of fat cell differentiation GO Biological Processes -17.6607153 22 More
GO:0045599 negative regulation of fat cell differentiation GO Biological Processes -10.0272645 11 More
GO:0045667 regulation of osteoblast differentiation GO Biological Processes -10.7517956 27 More
GO:0045669 positive regulation of osteoblast differentiation GO Biological Processes -8.83631876 18 More
GO:0045685 regulation of glial cell differentiation GO Biological Processes -7.97684638 17 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045779 negative regulation of bone resorption GO Biological Processes -4.33413085 4 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0046425 regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.5317026 20 More
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.8890337 15 More
GO:0046631 alpha-beta T cell activation GO Biological Processes -4.13140497 7 More
GO:0046632 alpha-beta T cell differentiation GO Biological Processes -3.95887136 6 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046850 regulation of bone remodeling GO Biological Processes -7.11509809 13 More
GO:0046851 negative regulation of bone remodeling GO Biological Processes -4.18483678 6 More
GO:0046879 hormone secretion GO Biological Processes -6.27678757 15 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048710 regulation of astrocyte differentiation GO Biological Processes -5.46031079 9 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0048872 homeostasis of number of cells GO Biological Processes -12.0072872 22 More
GO:0050670 regulation of lymphocyte proliferation GO Biological Processes -22.6006415 32 More
GO:0050671 positive regulation of lymphocyte proliferation GO Biological Processes -19.1485102 24 More
GO:0050673 epithelial cell proliferation GO Biological Processes -5.54644403 9 More
GO:0050708 regulation of protein secretion GO Biological Processes -30.3716714 63 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.9747849 34 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050768 negative regulation of neurogenesis GO Biological Processes -6.01402466 11 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050778 positive regulation of immune response GO Biological Processes -17.2528761 40 More
GO:0050796 regulation of insulin secretion GO Biological Processes -13.8348879 19 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050829 defense response to Gram-negative bacterium GO Biological Processes -15.0142277 17 More
GO:0050830 defense response to Gram-positive bacterium GO Biological Processes -13.1972375 17 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050864 regulation of B cell activation GO Biological Processes -7.98662389 16 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050871 positive regulation of B cell activation GO Biological Processes -8.77049404 15 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051054 positive regulation of DNA metabolic process GO Biological Processes -3.76901955 13 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051223 regulation of protein transport GO Biological Processes -25.2801266 81 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051384 response to glucocorticoid GO Biological Processes -16.9609899 22 More
GO:0051607 defense response to virus GO Biological Processes -3.02916189 22 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051961 negative regulation of nervous system development GO Biological Processes -6.75305746 12 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060147 regulation of post-transcriptional gene silencing GO Biological Processes -6.75865733 12 More
GO:0060148 positive regulation of post-transcriptional gene silencing GO Biological Processes -3.60377864 4 More
GO:0060249 anatomical structure homeostasis GO Biological Processes -12.3640817 24 More
GO:0060251 regulation of glial cell proliferation GO Biological Processes -8.90876897 12 More
GO:0060252 positive regulation of glial cell proliferation GO Biological Processes -5.51502780 7 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0060761 negative regulation of response to cytokine stimulus GO Biological Processes -10.5179624 22 More
GO:0060964 regulation of miRNA-mediated gene silencing GO Biological Processes -7.13447853 12 More
GO:0060966 regulation of gene silencing by RNA GO Biological Processes -6.64085561 12 More
GO:0061008 hepaticobiliary system development GO Biological Processes -10.9353398 26 More
GO:0062197 cellular response to chemical stress GO Biological Processes -14.0979689 44 More
GO:0070201 regulation of establishment of protein localization GO Biological Processes -24.4831554 82 More
GO:0070301 cellular response to hydrogen peroxide GO Biological Processes -5.36006230 13 More
GO:0070663 regulation of leukocyte proliferation GO Biological Processes -26.8242532 37 More
GO:0070665 positive regulation of leukocyte proliferation GO Biological Processes -21.5362473 27 More
GO:0070741 response to interleukin-6 GO Biological Processes -9.27147512 9 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0070920 regulation of production of small RNA involved in gene silencing by RNA GO Biological Processes -5.08699974 5 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071345 cellular response to cytokine stimulus GO Biological Processes -39.647808 70 More
GO:0071354 cellular response to interleukin-6 GO Biological Processes -8.31494447 8 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071887 leukocyte apoptotic process GO Biological Processes -3.56106200 4 More
GO:0090087 regulation of peptide transport GO Biological Processes -16.3568662 23 More
GO:0090276 regulation of peptide hormone secretion GO Biological Processes -16.6841590 23 More
GO:0090330 regulation of platelet aggregation GO Biological Processes -3.43776968 4 More
GO:0097421 liver regeneration GO Biological Processes -7.12111476 7 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0098586 cellular response to virus GO Biological Processes -6.52248641 17 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098802 plasma membrane signaling receptor complex GO Cellular Components -6.47096721 17 More
GO:0140352 export from cell GO Biological Processes -8.94733589 48 More
GO:0140546 defense response to symbiont GO Biological Processes -3.00647654 22 More
GO:0150077 regulation of neuroinflammatory response GO Biological Processes -14.4671881 13 More
GO:0150078 positive regulation of neuroinflammatory response GO Biological Processes -8.75781093 7 More
GO:1900368 regulation of post-transcriptional gene silencing by RNA GO Biological Processes -6.88005887 12 More
GO:1900370 positive regulation of post-transcriptional gene silencing by RNA GO Biological Processes -3.60377864 4 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903053 regulation of extracellular matrix organization GO Biological Processes -8.17680088 15 More
GO:1903055 positive regulation of extracellular matrix organization GO Biological Processes -4.01585848 7 More
GO:1903131 mononuclear cell differentiation GO Biological Processes -9.35861236 21 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -20.7768498 23 More
GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA GO Biological Processes -5.19429515 5 More
GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA GO Biological Processes -5.05315969 4 More
GO:1904035 regulation of epithelial cell apoptotic process GO Biological Processes -21.2824424 33 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
GO:1904894 positive regulation of receptor signaling pathway via STAT GO Biological Processes -11.2917234 16 More
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell GO Biological Processes -9.55155535 14 More
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell GO Biological Processes -8.04419623 7 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000551 regulation of T-helper 2 cell cytokine production GO Biological Processes -4.89406977 4 More
GO:2000553 positive regulation of T-helper 2 cell cytokine production GO Biological Processes -3.88065666 3 More
GO:2000637 positive regulation of miRNA-mediated gene silencing GO Biological Processes -3.67847337 4 More
GO:2000659 regulation of interleukin-1-mediated signaling pathway GO Biological Processes -4.56141436 5 More
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway GO Biological Processes -5.59447366 5 More
KEGG pathways: 51 records
KEGG Description Category LogP Number of genes Detail
hsa01521 EGFR tyrosine kinase inhibitor resistance KEGG Pathway -6.02704244 9 More
hsa01523 Antifolate resistance KEGG Pathway -5.90548425 6 More
hsa04060 Cytokine-cytokine receptor interaction KEGG Pathway -61.0014447 66 More
hsa04061 Viral protein interaction with cytokine and cytokine receptor KEGG Pathway -30.3399237 29 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04068 FoxO signaling pathway KEGG Pathway -6.87449445 21 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04218 Cellular senescence KEGG Pathway -5.14633043 11 More
hsa04620 Toll-like receptor signaling pathway KEGG Pathway -11.1460554 15 More
hsa04621 NOD-like receptor signaling pathway KEGG Pathway -7.63493695 15 More
hsa04623 Cytosolic DNA-sensing pathway KEGG Pathway -5.78243801 8 More
hsa04625 C-type lectin receptor signaling pathway KEGG Pathway -5.36927089 9 More
hsa04630 JAK-STAT signaling pathway KEGG Pathway -14.4088859 21 More
hsa04640 Hematopoietic cell lineage KEGG Pathway -11.4657972 15 More
hsa04657 IL-17 signaling pathway KEGG Pathway -16.8039621 19 More
hsa04659 Th17 cell differentiation KEGG Pathway -9.80516906 14 More
hsa04668 TNF signaling pathway KEGG Pathway -16.5384917 20 More
hsa04672 Intestinal immune network for IgA production KEGG Pathway -7.87779205 9 More
hsa04931 Insulin resistance KEGG Pathway -8.40376708 21 More
hsa04932 Non-alcoholic fatty liver disease KEGG Pathway -11.2628136 17 More
hsa04933 AGE-RAGE signaling pathway in diabetic complications KEGG Pathway -25.8646207 26 More
hsa04936 Alcoholic liver disease KEGG Pathway -13.3477535 19 More
hsa05010 Alzheimer disease KEGG Pathway -5.39034067 17 More
hsa05020 Prion disease KEGG Pathway -2.47073365 10 More
hsa05022 Pathways of neurodegeneration - multiple diseases KEGG Pathway -4.18311884 18 More
hsa05130 Pathogenic Escherichia coli infection KEGG Pathway -9.84822677 18 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
hsa05133 Pertussis KEGG Pathway -13.2270528 15 More
hsa05134 Legionellosis KEGG Pathway -13.8022551 14 More
hsa05135 Yersinia infection KEGG Pathway -7.02427022 12 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05143 African trypanosomiasis KEGG Pathway -18.5080428 15 More
hsa05144 Malaria KEGG Pathway -31.5561809 24 More
hsa05146 Amoebiasis KEGG Pathway -14.8474637 18 More
hsa05152 Tuberculosis KEGG Pathway -14.5221547 22 More
hsa05161 Hepatitis B KEGG Pathway -5.78517620 12 More
hsa05162 Measles KEGG Pathway -4.80674483 10 More
hsa05163 Human cytomegalovirus infection KEGG Pathway -9.77103740 19 More
hsa05164 Influenza A KEGG Pathway -16.0885267 23 More
hsa05166 Human T-cell leukemia virus 1 infection KEGG Pathway -5.08552863 13 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05168 Herpes simplex virus 1 infection KEGG Pathway -3.99478875 17 More
hsa05169 Epstein-Barr virus infection KEGG Pathway -3.79267986 10 More
hsa05171 Coronavirus disease - COVID-19 KEGG Pathway -24.8179886 34 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05321 Inflammatory bowel disease KEGG Pathway -16.3800424 16 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
hsa05332 Graft-versus-host disease KEGG Pathway -5.01134628 6 More
hsa05410 Hypertrophic cardiomyopathy KEGG Pathway -9.74858067 13 More
hsa05417 Lipid and atherosclerosis KEGG Pathway -33.3876857 40 More
Drug-Gene interaction
view
Related drugs: 25 records
Drug name Interaction type Source PMID View
adalimumab PharmGKB 24253594 view
cisplatin CIViC 21273582 view
clazakizumab inhibitor TdgClinicalTrialChemblInteractionsTTD view
cor-001 TTD view
echinacea, unspecified NCI 9568541 view
elsilimomab inhibitor ChemblInteractions view
etanercept PharmGKB 24253594 view
fenofibrate PharmGKB 16607077 view
fentanyl NCI 9527747 view
gemfibrozil NCI 8941582 view
ibudilast TTD view
ifosfamide NCI 9260581 view
infliximab PharmGKB 24253594 view
insulin NCI 17392554 view
levofloxacin NCI 12714806 view
linezolid NCI 14561977 view
metronidazole NCI 12111578 view
nelfinavir NCI 15388451 view
olokizumab inhibitor TdgClinicalTrialChemblInteractionsTTD 24641941 view
pf-04236921 inhibitor ChemblInteractionsTTD view
ribavirin PharmGKB view
rituximab PharmGKB 26384320 view
saquinavir NCI 15388451 view
siltuximab antagonistantibodyinhibitor MyCancerGenomeChemblInteractionsTTD 8823310 view
sirukumab inhibitor ChemblInteractionsTTD view
Related studies: 84 records
Molecular factor Omics type Application Objective MI type Reference
IL6 transcriptomics acute myocardial infarction[diagnosis] acute myocardial infarction Anderson DR et al. Cytokine. 2013
NM_001992.5:c.[-1738G>A;-506GGCCGCGGGAAGC[3];2860G>A;88+693C>A;88+6876C>A;88+7096C>T;*1468T>C]*NM_000600.5:c.[-174G>C;-572G>C;324+147C>G] genomics myocardial infarction[diagnosis] myocardial infarction Gigante B et al. PLoS One. 2010
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ikeda U et al. J Mol Cell Cardiol. 1992
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Sturk A et al. J Lab Clin Med. 1992
interleukin-6 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Miyao Y et al. Am Heart J. 1993
interleukin-6 proteomics Mac-1 cell[other] acute ST elevation myocardial infarction Ott I et al. Am J Cardiol. 1998
interleukin-6 proteomics magnesium[treatment (pharmacotherapy)] acute myocardial infarction Shibata M et al. Angiology. 1999
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ueda K et al. Am Heart J. 1999
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Ridker PM et al. Circulation. 2000
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kotajima N et al. Rinsho Byori. 2000
interleukin-6 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Kimura T et al. Eur J Endocrinol. 2000
interleukin-6 proteomics euthyroid sick syndrome[prognosis (bad)] acute ST elevation myocardial infarction Kimura T et al. Eur J Endocrinol. 2000
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Gabriel AS et al. J Intern Med. 2000
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kanda T et al. Cardiology. 2000
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Nishino M et al. J Endocrinol Invest. 2000
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kucharz EJ et al. Eur J Intern Med. 2000
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Balbay Y et al. Angiology. 2001
interleukin-6 proteomics thyroid hormone[other] acute myocardial infarction Kimur T et al. Res Commun Mol Pathol Pharmacol. 2001
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dominguez Rodriguez A et al. Rev Esp Cardiol. 2003
interleukin-6 proteomics death[prognosis (bad)] myocardial infarction Marciniak A et al. Pol Arch Med Wewn. 2003
interleukin-6 proteomics magnesium[treatment (pharmacotherapy)] acute myocardial infarction Ueshima K et al. Magnes Res. 2003
interleukin-6 proteomics congestive heart failure[prognosis (bad)] acute myocardial infarction Ueshima K et al. Magnes Res. 2003
interleukin-6 proteomics myocardial infarction[diagnosis] myocardial infarction Bennet AM et al. Atherosclerosis. 2003
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Dominguez-Rodriguez A et al. Cytokine. 2004
interleukin-6 proteomics infarct-related artery[other] acute ST elevation myocardial infarction Funayama H et al. Circ J. 2004
interleukin-6 proteomics left ventricular remodeling[prognosis (bad)] acute anterior myocardial infarction Ohtsuka T et al. Clin Cardiol. 2004
interleukin-6 proteomics plaque rupture[other] acute myocardial infarction Maier W et al. Circulation. 2005
interleukin-6 proteomics collateral circulation[prognosis (good)] acute myocardial infarction Rakhit RD et al. Coron Artery Dis. 2005
interleukin-6 proteomics type 2 diabetes mellitus[prognosis (bad)] acute myocardial infarction Nystrom T et al. Clin Sci (Lond). 2006
interleukin-6 proteomics coronary restenosis[prognosis (bad)] acute myocardial infarction Funayama H et al. Circ J. 2006
interleukin-6 proteomics complication[prognosis (bad)] acute ST elevation myocardial infarction Ziakas A et al. Angiology. 2006
interleukin-6 proteomics good predictor death[prognosis (bad)] acute myocardial infarction Geppert A et al. Crit Care Med. 2006
interleukin-6 proteomics endothelial dysfunction[prognosis (bad)] old myocardial infarction Erzen B et al. Cardiology. 2007
interleukin-6 proteomics medium predictor acute myocardial infarction[diagnosis] acute myocardial infarction Ferroni P et al. Clin Chim Acta. 2007
interleukin-6 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Suzuki H et al. Eur J Clin Invest. 2008
interleukin-6 proteomics adverse events[prognosis (bad)] acute myocardial infarction Jaremo P et al. Eur J Intern Med. 2008
interleukin-6 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Tan J et al. Clin Cardiol. 2008
interleukin-6 proteomics cardiovascular death[prognosis (bad)] acute ST elevation myocardial infarction Tan J et al. Clin Cardiol. 2008
interleukin-6 proteomics left ventricular diastolic dysfunction[prognosis (bad)] acute ST elevation myocardial infarction Karpinski L et al. Kardiol Pol. 2008
interleukin-6 proteomics left ventricular systolic dysfunction[prognosis (bad)] acute ST elevation myocardial infarction Karpinski L et al. Kardiol Pol. 2008
interleukin-6 proteomics inflammation[prognosis (bad)] acute ST elevation myocardial infarction Karpinski L et al. Pol Arch Med Wewn. 2009
interleukin-6 proteomics cardiovascular death[prognosis (bad)] acute ST elevation myocardial infarction Tan J et al. Heart Vessels. 2009
interleukin-6 proteomics death[prognosis (bad)] acute ST elevation myocardial infarction Borrayo-Sanchez G et al. Cir Cir. 2010
interleukin-6 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Borrayo-Sanchez G et al. Cir Cir. 2010
interleukin-6 proteomics cardiovascular death[prognosis (bad)] acute ST elevation myocardial infarction Fan ZX et al. Cell Biochem Biophys. 2011
interleukin-6 proteomics good predictor death[prognosis (bad)] acute myocardial infarction Prondzinsky R et al. Clin Res Cardiol. 2012
interleukin-6 proteomics death[prognosis (bad)] acute myocardial infarction Andrie RP et al. Crit Care. 2012
interleukin-6 proteomics poor predictor death[prognosis (bad)] acute ST elevation myocardial infarction Ammirati E et al. Circ Res. 2012
interleukin-6 proteomics poor predictor death;recurrent myocardial infarction[prognosis (bad)] acute ST elevation myocardial infarction Ammirati E et al. Circ Res. 2012
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Anderson DR et al. Cytokine. 2013
interleukin-6 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kang B et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014
interleukin-6 proteomics coenzyme Q10[treatment (pharmacotherapy)] acute myocardial infarction Mohseni M et al. Int J Prev Med. 2015
interleukin-6 proteomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Diebold S et al. Diabetes Obes Metab. 2018
interleukin-6 proteomics tirofiban[treatment (pharmacotherapy)] acute myocardial infarction Zhang Y et al. Exp Ther Med. 2018
interleukin-6 proteomics E/E' wave ratio[other] acute ST elevation myocardial infarction Groot HE et al. Clin Res Cardiol. 2019
interleukin-6 proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Groot HE et al. Clin Res Cardiol. 2019
interleukin-6 proteomics infarct size[other] acute ST elevation myocardial infarction Groot HE et al. Clin Res Cardiol. 2019
interleukin-6 proteomics coronary vessel lesion[other] acute ST elevation myocardial infarction Cao Y et al. Exp Ther Med. 2019
interleukin-6 proteomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Cao Y et al. Exp Ther Med. 2019
interleukin-6 proteomics medium predictor heart failure[prognosis (bad)] acute ST elevation myocardial infarction Lino DOC et al. Braz J Med Biol Res. 2019
interleukin-6 proteomics major adverse cardiovascular events[prognosis (bad)] acute ST elevation myocardial infarction Ljuca F et al. Saudi Med J. 2019
interleukin-6 proteomics infarct size[other] acute ST elevation myocardial infarction Butt N et al. Eur Heart J Acute Cardiovasc Care. 2020
interleukin-6 proteomics atorvastatin plus bivalirudin[treatment (pharmacotherapy)] acute myocardial infarction Dong SH et al. Ann Palliat Med. 2020
interleukin-6 proteomics left ventricular ejection fraction[other] acute ST elevation myocardial infarction Coste MER et al. Arq Bras Cardiol. 2020
interleukin-6 proteomics major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Kristono GA et al. Cytokine X. 2020
NM_000600.5:c.-174G>C genomics myocardial infarction[diagnosis] myocardial infarction Bennet AM et al. Atherosclerosis. 2003
NM_000600.5:c.-174G>C genomics myocardial infarction[diagnosis] myocardial infarction Kelberman D et al. Thromb Haemost. 2004
NM_000600.5:c.-174G>C genomics myocardial infarction[diagnosis] myocardial infarction Rosner SA et al. Hum Genet. 2005
NM_000600.5:c.-174G>C genomics myocardial infarction[diagnosis] myocardial infarction Ortlepp JR et al. Int J Cardiol. 2005
NM_000600.5:c.-174G>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Chiappelli M et al. Int J Immunogenet. 2005
NM_000600.5:c.-572G>C genomics myocardial infarction[diagnosis] myocardial infarction Fu HX et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
NM_000600.5:c.-572G>C genomics myocardial infarction[diagnosis] myocardial infarction Podgoreanu MV et al. Circulation. 2006
NM_000600.5:c.-174G>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Vakili H et al. Coron Artery Dis. 2011
NM_000600.5:c.-174G>C genomics hyperglycemia[prognosis (bad)] acute myocardial infarction Lima-Neto LG et al. J Thromb Thrombolysis. 2013
NM_000600.5:c.-174G>C genomics hypertriglyceridemia[prognosis (bad)] acute myocardial infarction Lima-Neto LG et al. J Thromb Thrombolysis. 2013
NM_000600.5:c.-174G>C genomics myocardial infarction[diagnosis] myocardial infarction Panasevich S et al. BMJ Open. 2013
NM_000600.5:c.-598G>A genomics myocardial infarction[diagnosis] myocardial infarction Panasevich S et al. BMJ Open. 2013
NM_000600.5:c.-174G>C genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Biswas S et al. Gene. 2014
NM_000600.5:c.-572G>C genomics myocardial infarction[diagnosis] myocardial infarction Nassibulin TR et al. Genetika. 2014
interleukin-6 proteomics poor predictor acute myocardial infarction[diagnosis] acute myocardial infarction Van Lente F et al. Clin Chem. 1995
interleukin-6 proteomics death;shock[prognosis (bad)] acute ST elevation myocardial infarction Theroux P et al. Eur Heart J. 2005
interleukin-6 proteomics myocardial infarction[diagnosis] myocardial infarction Wennberg P et al. Thromb Res. 2012
interleukin-6 proteomics enoxaparin[treatment (pharmacotherapy)] ST elevation myocardial infarction Nasiripour S et al. Iran J Pharm Res. 2014
interleukin-6 proteomics medium predictor type 2 diabetes mellitus[prognosis (bad)] ST elevation myocardial infarction Barbarash O et al. Arch Med Sci. 2017
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